Distal Effect of Amino Acid Substitutions in CYP2C9 Polymorphic Variants Causes Differences in Interatomic Interactions against (S)-Warfarin

• Panida Lertkiatmongkol,

  Affiliations Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand, Genomics Institute, National Center for Genetic Engineering and Biotechnology, Pathumtani, Thailand, Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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• Anunchai Assawamakin,

  Affiliation Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand

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• George White,

  Affiliation Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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• Gaurav Chopra,

  Affiliations Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America

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• Pornpimol Rongnoparut,

  Affiliation Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand

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• Ram Samudrala,

  Affiliation Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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• Sissades Tongsima

  * E-mail: sissades@biotec.or.th

  Affiliation Genomics Institute, National Center for Genetic Engineering and Biotechnology, Pathumtani, Thailand

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