Unique Structure and Dynamics of the EphA5 Ligand Binding Domain Mediate Its Binding Specificity as Revealed by X-ray Crystallography, NMR and MD Simulations

Xuelu Huan; Jiahai Shi; Liangzhong Lim; Sayantan Mitra; Wanlong Zhu; Haina Qin; Elena B. Pasquale; Jianxing Song

doi:10.1371/journal.pone.0074040

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Peer-reviewed

Research Article

Unique Structure and Dynamics of the EphA5 Ligand Binding Domain Mediate Its Binding Specificity as Revealed by X-ray Crystallography, NMR and MD Simulations

Xuelu Huan ,

Contributed equally to this work with: Xuelu Huan, Jiahai Shi, Liangzhong Lim

Affiliation NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Republic of Singapore
⨯
Jiahai Shi ,

Contributed equally to this work with: Xuelu Huan, Jiahai Shi, Liangzhong Lim

Current address: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore
⨯
Liangzhong Lim ,

Contributed equally to this work with: Xuelu Huan, Jiahai Shi, Liangzhong Lim

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore
⨯
Sayantan Mitra,

Affiliation Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
⨯
Wanlong Zhu,

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore
⨯
Haina Qin,

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore
⨯
Elena B. Pasquale,

Affiliations Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America, Pathology Department, University of California San Diego, La Jolla, California, United States of America
⨯
Jianxing Song

* E-mail: bchsj@nus.edu.sg

Affiliations NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Republic of Singapore, Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
⨯

Unique Structure and Dynamics of the EphA5 Ligand Binding Domain Mediate Its Binding Specificity as Revealed by X-ray Crystallography, NMR and MD Simulations

Xuelu Huan,
Jiahai Shi,
Liangzhong Lim,
Sayantan Mitra,
Wanlong Zhu,
Haina Qin,
Elena B. Pasquale,
Jianxing Song

Published: September 24, 2013
https://doi.org/10.1371/journal.pone.0074040

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