Zygotic G2/M Cell Cycle Arrest Induced by ATM/Chk1 Activation and DNA Repair in Mouse Embryos Fertilized with Hydrogen Peroxide-Treated Epididymal Mouse Sperm

Bin Wang; Zhiling Li; Chao Wang; Man Chen; Jianfeng Xiao; Xiaoyan Wu; Wanfen Xiao; Yu Song; Xiaoyan Wang

doi:10.1371/journal.pone.0073987

Loading metrics

Open Access

Peer-reviewed

Research Article

Zygotic G2/M Cell Cycle Arrest Induced by ATM/Chk1 Activation and DNA Repair in Mouse Embryos Fertilized with Hydrogen Peroxide-Treated Epididymal Mouse Sperm

Bin Wang ,

Contributed equally to this work with: Bin Wang, Zhiling Li, Chao Wang

Affiliation Reproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, Guangdong, People’s Republic of China
⨯
Zhiling Li ,

Contributed equally to this work with: Bin Wang, Zhiling Li, Chao Wang

* E-mail: stlizhiling@126.com

Affiliation Reproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, Guangdong, People’s Republic of China
⨯
Chao Wang ,

Contributed equally to this work with: Bin Wang, Zhiling Li, Chao Wang

Affiliation Reproductive Center, The Affiliated Hospital of Jining Medical College, Jining, Shandong, People’s Republic of China
⨯
Man Chen,

Affiliation Reproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, Guangdong, People’s Republic of China
⨯
Jianfeng Xiao,

Affiliation Reproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, Guangdong, People’s Republic of China
⨯
Xiaoyan Wu,

Affiliation Reproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, Guangdong, People’s Republic of China
⨯
Wanfen Xiao,

Affiliation Reproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, Guangdong, People’s Republic of China
⨯
Yu Song,

Affiliation Reproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, Guangdong, People’s Republic of China
⨯
Xiaoyan Wang

Affiliation Reproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, Guangdong, People’s Republic of China
⨯

Zygotic G2/M Cell Cycle Arrest Induced by ATM/Chk1 Activation and DNA Repair in Mouse Embryos Fertilized with Hydrogen Peroxide-Treated Epididymal Mouse Sperm

Bin Wang,
Zhiling Li,
Chao Wang,
Man Chen,
Jianfeng Xiao,
Xiaoyan Wu,
Wanfen Xiao,
Yu Song,
Xiaoyan Wang

Published: September 10, 2013
https://doi.org/10.1371/journal.pone.0073987

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Sperm
Is the Subject Area "Sperm" applicable to this article?

Thanks for your feedback.
Embryos
Is the Subject Area "Embryos" applicable to this article?

Thanks for your feedback.
Zygotes
Is the Subject Area "Zygotes" applicable to this article?

Thanks for your feedback.
DNA damage
Is the Subject Area "DNA damage" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
DNA repair
Is the Subject Area "DNA repair" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
G1 phase
Is the Subject Area "G1 phase" applicable to this article?

Thanks for your feedback.