Determining Ancestry Proportions in Complex Admixture Scenarios in South Africa Using a Novel Proxy Ancestry Selection Method

Emile R. Chimusa; Michelle Daya; Marlo Möller; Raj Ramesar; Brenna M. Henn; Paul D. van Helden; Nicola J. Mulder; Eileen G. Hoal

doi:10.1371/journal.pone.0073971

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Peer-reviewed

Research Article

Determining Ancestry Proportions in Complex Admixture Scenarios in South Africa Using a Novel Proxy Ancestry Selection Method

Emile R. Chimusa,

Affiliation Computational Biology Group, Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Cape Town, South Africa
⨯
Michelle Daya,

Affiliation MRC Centre for Molecular and Cellular Biology, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Marlo Möller,

Affiliation MRC Centre for Molecular and Cellular Biology, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Raj Ramesar,

Affiliation MRC Human Genetics Research Unit, Division of Human Genetics, Department of Clinical Laboratory Sciences, Institute for Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
⨯
Brenna M. Henn,

Affiliations Department of Genetics, Stanford University, Stanford, California, United States of America, Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York, United States of America
⨯
Paul D. van Helden,

Affiliation MRC Centre for Molecular and Cellular Biology, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Nicola J. Mulder,

Affiliation Computational Biology Group, Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Cape Town, South Africa
⨯
Eileen G. Hoal

* E-mail: egvh@sun.ac.za

Affiliation MRC Centre for Molecular and Cellular Biology, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯

Determining Ancestry Proportions in Complex Admixture Scenarios in South Africa Using a Novel Proxy Ancestry Selection Method

Emile R. Chimusa,
Michelle Daya,
Marlo Möller,
Raj Ramesar,
Brenna M. Henn,
Paul D. van Helden,
Nicola J. Mulder,
Eileen G. Hoal

Published: September 16, 2013
https://doi.org/10.1371/journal.pone.0073971

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