In Silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP₄ Mediated Feedbacks Increase Robustness

• Sayak Mukherjee,

  Affiliation Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children’s Hospital, Columbus, Ohio, United States of America

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• Stephanie Rigaud,

  Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• Sang-Cheol Seok,

  Affiliation Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children’s Hospital, Columbus, Ohio, United States of America

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• Guo Fu,

  Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• Agnieszka Prochenka,

  Affiliations Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children’s Hospital, Columbus, Ohio, United States of America, Institute of Computer Science, Polish Academy of Sciences, Warsaw, Poland

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• Michael Dworkin,

  Affiliations Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children’s Hospital, Columbus, Ohio, United States of America, Department of Mathematics, The Ohio State University, Columbus, Ohio, United States of America

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• Nicholas R. J. Gascoigne,

  Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• Veronica J. Vieland,

  Affiliations Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children’s Hospital, Columbus, Ohio, United States of America, Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America, Department of Statistics, The Ohio State University, Columbus, Ohio, United States of America

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• Karsten Sauer ,

  * E-mail: ksauer@scripps.edu (KS); Jayajit.Das@nationwidechildrens.org (JD)

  Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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• Jayajit Das

  * E-mail: ksauer@scripps.edu (KS); Jayajit.Das@nationwidechildrens.org (JD)

  Affiliations Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children’s Hospital, Columbus, Ohio, United States of America, Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America, Department of Physics, The Ohio State University, Columbus, Ohio, United States of America, Biophysics Graduate Program, The Ohio State University, Columbus, Ohio, United States of America

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