A Randomised, Placebo-Controlled, First-In-Human Study of a Novel Clade C Therapeutic Peptide Vaccine Administered Ex Vivo to Autologous White Blood Cells in HIV Infected Individuals

Akil Jackson; Henrik N. Kløverpris; Marta Boffito; Amanda Handley; Mark Atkins; Peter Hayes; Jill Gilmour; Lynn Riddel; Fabian Chen; Melanie Bailey-Tippets; Bruce Walker; Jim Ackland; Mark Sullivan; Philip Goulder

doi:10.1371/journal.pone.0073765

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Open Access

Peer-reviewed

Research Article

A Randomised, Placebo-Controlled, First-In-Human Study of a Novel Clade C Therapeutic Peptide Vaccine Administered Ex Vivo to Autologous White Blood Cells in HIV Infected Individuals

Akil Jackson ,

* E-mail: akil.jackson@chelwest.nhs.uk

Affiliation St Stephen’s AIDS Trust, Chelsea and Westminster Hospital, London, United Kingdom
⨯
Henrik N. Kløverpris,

Affiliations Department of Paediatrics, University of Oxford, Oxford, United Kingdom, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark, KwaZulu-Natal Research Institute for Tuberculosis and HIV, K-RITH, University of Kwazulu-Natal, Durban, South Africa
⨯
Marta Boffito,

Affiliation St Stephen’s AIDS Trust, Chelsea and Westminster Hospital, London, United Kingdom
⨯
Amanda Handley,

Affiliation Medicines Development, Melbourne, Victoria, Australia
⨯
Mark Atkins,

Affiliation Imperial College, London, United Kingdom
⨯
Peter Hayes,

Affiliation Imperial College, London, United Kingdom
⨯
Jill Gilmour,

Affiliation Imperial College, London, United Kingdom
⨯
Lynn Riddel,

Affiliation Department of Genitourinary Medicine, Northampton General Hospital, Northampton, United Kingdom
⨯
Fabian Chen,

Affiliation Department of Sexual Health, Royal Berkshire Hospital, Reading, United Kingdom
⨯
Melanie Bailey-Tippets,

Affiliation INC, Oakleigh, Victoria, Australia
⨯
Bruce Walker,

Affiliation Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Boston, Massachusetts, United States of America
⨯
Jim Ackland,

Affiliation Global Biosolutions, Craigieburn, Victoria, Australia
⨯
Mark Sullivan,

Affiliation Medicines Development, Melbourne, Victoria, Australia
⨯
Philip Goulder

Affiliations Department of Paediatrics, University of Oxford, Oxford, United Kingdom, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Boston, Massachusetts, United States of America
⨯

A Randomised, Placebo-Controlled, First-In-Human Study of a Novel Clade C Therapeutic Peptide Vaccine Administered Ex Vivo to Autologous White Blood Cells in HIV Infected Individuals

Akil Jackson,
Henrik N. Kløverpris,
Marta Boffito,
Amanda Handley,
Mark Atkins,
Peter Hayes,
Jill Gilmour,
Lynn Riddel,
Fabian Chen,
Melanie Bailey-Tippets

Published: September 17, 2013
https://doi.org/10.1371/journal.pone.0073765

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