Mathematical Model for Radial Expansion and Conflation of Intratumoral Infectious Centers Predicts Curative Oncolytic Virotherapy Parameters

Kent Bailey; Amber Kirk; Shruthi Naik; Rebecca Nace; Michael B. Steele; Lukkana Suksanpaisan; Xing Li; Mark J. Federspiel; Kah-Whye Peng; David Kirk; Stephen J. Russell

doi:10.1371/journal.pone.0073759

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Research Article

Mathematical Model for Radial Expansion and Conflation of Intratumoral Infectious Centers Predicts Curative Oncolytic Virotherapy Parameters

Kent Bailey ,

Contributed equally to this work with: Kent Bailey, Amber Kirk, Shruthi Naik

Affiliation Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Amber Kirk ,

Contributed equally to this work with: Kent Bailey, Amber Kirk, Shruthi Naik

Affiliations Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Shruthi Naik ,

Contributed equally to this work with: Kent Bailey, Amber Kirk, Shruthi Naik

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Rebecca Nace,

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Michael B. Steele,

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Lukkana Suksanpaisan,

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Xing Li,

Affiliation Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Mark J. Federspiel,

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Kah-Whye Peng,

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
David Kirk,

Affiliation Consulpack, Inc., Minneapolis, Minnesota, United States of America
⨯
Stephen J. Russell

* E-mail: sjr@mayo.edu

Affiliations Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America, Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

Mathematical Model for Radial Expansion and Conflation of Intratumoral Infectious Centers Predicts Curative Oncolytic Virotherapy Parameters

Kent Bailey,
Amber Kirk,
Shruthi Naik,
Rebecca Nace,
Michael B. Steele,
Lukkana Suksanpaisan,
Xing Li,
Mark J. Federspiel,
Kah-Whye Peng,
David Kirk

Published: September 11, 2013
https://doi.org/10.1371/journal.pone.0073759

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