Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids in Cellular Recovery after Quinone Exposure

J. Peter Svensson; Laia Quirós Pesudo; Siobhan K. McRee; Yeyejide Adeleye; Paul Carmichael; Leona D. Samson

doi:10.1371/journal.pone.0073736

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Research Article

Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids in Cellular Recovery after Quinone Exposure

J. Peter Svensson,

Affiliations Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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Laia Quirós Pesudo,

Affiliations Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Siobhan K. McRee,

Affiliation Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Yeyejide Adeleye,

Affiliation Safety & Environmental Assurance Centre, Unilever, Sharnbrook, Bedfordshire, United Kingdom
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Paul Carmichael,

Affiliation Safety & Environmental Assurance Centre, Unilever, Sharnbrook, Bedfordshire, United Kingdom
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Leona D. Samson

* E-mail: lsamson@mit.edu

Affiliations Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Biology Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯

Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids in Cellular Recovery after Quinone Exposure

J. Peter Svensson,
Laia Quirós Pesudo,
Siobhan K. McRee,
Yeyejide Adeleye,
Paul Carmichael,
Leona D. Samson

Published: September 9, 2013
https://doi.org/10.1371/journal.pone.0073736

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