Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer

Kyle R. Cron; Kaya Zhu; Deepa S. Kushwaha; Grace Hsieh; Dmitry Merzon; Jonathan Rameseder; Clark C. Chen; Alan D. D’Andrea; David Kozono

doi:10.1371/journal.pone.0073710

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Open Access

Peer-reviewed

Research Article

Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer

Kyle R. Cron ,

Contributed equally to this work with: Kyle R. Cron, Kaya Zhu

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Kaya Zhu ,

Contributed equally to this work with: Kyle R. Cron, Kaya Zhu

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Deepa S. Kushwaha,

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Grace Hsieh,

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Dmitry Merzon,

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Jonathan Rameseder,

Affiliation Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Clark C. Chen,

Affiliation Division of Neurosurgery, University of California San Diego, San Diego, California, United States of America
⨯
Alan D. D’Andrea,

Affiliations Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
David Kozono

* E-mail: dkozono@lroc.harvard.edu

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯

Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer

Kyle R. Cron,
Kaya Zhu,
Deepa S. Kushwaha,
Grace Hsieh,
Dmitry Merzon,
Jonathan Rameseder,
Clark C. Chen,
Alan D. D’Andrea,
David Kozono

Published: September 5, 2013
https://doi.org/10.1371/journal.pone.0073710

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Proteasomes
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Non-small cell lung cancer
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Cancer treatment
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DNA repair
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Radiation therapy
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Malignant tumors
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Cancers and neoplasms
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Proteasome inhibitors
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