Synergistic Apoptosis of CML Cells by Buthionine Sulfoximine and Hydroxychavicol Correlates with Activation of AIF and GSH-ROS-JNK-ERK-iNOS Pathway

Avik Acharya Chowdhury; Jaydeep Chaudhuri; Nabendu Biswas; Anirban Manna; Saurav Chatterjee; Sanjit K. Mahato; Utpal Chaudhuri; Parasuraman Jaisankar; Santu Bandyopadhyay

doi:10.1371/journal.pone.0073672

Loading metrics

Open Access

Peer-reviewed

Research Article

Synergistic Apoptosis of CML Cells by Buthionine Sulfoximine and Hydroxychavicol Correlates with Activation of AIF and GSH-ROS-JNK-ERK-iNOS Pathway

Avik Acharya Chowdhury,

Affiliation Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), Kolkata, India
⨯
Jaydeep Chaudhuri,

Affiliation Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), Kolkata, India
⨯
Nabendu Biswas,

Current address: Department of Biotechnology, Presidency University, Kolkata, India

Affiliation Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), Kolkata, India
⨯
Anirban Manna,

Affiliation Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), Kolkata, India
⨯
Saurav Chatterjee,

Affiliation Division of Chemistry, CSIR-IICB, Kolkata, India
⨯
Sanjit K. Mahato,

Current address: Department of Chemistry, University of Johannesburg, South Africa

Affiliation Division of Chemistry, CSIR-IICB, Kolkata, India
⨯
Utpal Chaudhuri,

Affiliation The Institute of Hematology and Transfusion Medicine, Medical College, Kolkata, India
⨯
Parasuraman Jaisankar,

Affiliation Division of Chemistry, CSIR-IICB, Kolkata, India
⨯
Santu Bandyopadhyay

* E-mail: santu2@iicb.res.in

Affiliation Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB), Kolkata, India
⨯

Synergistic Apoptosis of CML Cells by Buthionine Sulfoximine and Hydroxychavicol Correlates with Activation of AIF and GSH-ROS-JNK-ERK-iNOS Pathway

Avik Acharya Chowdhury,
Jaydeep Chaudhuri,
Nabendu Biswas,
Anirban Manna,
Saurav Chatterjee,
Sanjit K. Mahato,
Utpal Chaudhuri,
Parasuraman Jaisankar,
Santu Bandyopadhyay

Published: September 9, 2013
https://doi.org/10.1371/journal.pone.0073672

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Nitric oxide
Is the Subject Area "Nitric oxide" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Prostate cancer
Is the Subject Area "Prostate cancer" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.