Brain White Matter Shape Changes in Amyotrophic Lateral Sclerosis (ALS): A Fractal Dimension Study

• Venkateswaran Rajagopalan ,

  Contributed equally to this work with: Venkateswaran Rajagopalan, Zao Liu

  Affiliations Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America

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• Zao Liu ,

  Contributed equally to this work with: Venkateswaran Rajagopalan, Zao Liu

  Affiliation Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Didier Allexandre,

  Affiliations Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America

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• Luduan Zhang,

  Current address: LZ Biomedical, LLC, Westminster, Colorado, United States of America

  Affiliation Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Xiao-Feng Wang,

  Affiliation Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Erik P. Pioro,

  Affiliations Neuromuscular Center and Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Guang H. Yue

  * E-mail: gyue@kesslerfoundation.org

  Affiliations Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America, Department of Physical Medicine & Rehabilitation, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America

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