Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP3 Receptor

Giovanni Monaco; Elke Decrock; Koen Nuyts; Larry E. Wagner II; Tomas Luyten; Sergei V. Strelkov; Ludwig Missiaen; Wim M. De Borggraeve; Luc Leybaert; David I. Yule; Humbert De Smedt; Jan B. Parys; Geert Bultynck

doi:10.1371/journal.pone.0073386

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Open Access

Peer-reviewed

Research Article

Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP₃ Receptor

Giovanni Monaco ,

* E-mail: Geert.Bultynck@med.kuleuven.be (GB); Giovanni.Monaco@med.kuleuven.be (GM)

Affiliation Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven, Belgium
⨯
Elke Decrock,

Affiliation Department of Basic Medical Sciences, Physiology Group, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
⨯
Koen Nuyts,

Affiliation Section of Molecular Design and Synthesis, Department of Chemistry, Heverlee, Belgium
⨯
Larry E. Wagner II,

Affiliation Department of Pharmacology & Physiology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Tomas Luyten,

Affiliation Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven, Belgium
⨯
Sergei V. Strelkov,

Affiliation Laboratory for Biocrystallography, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium
⨯
Ludwig Missiaen,

Affiliation Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven, Belgium
⨯
Wim M. De Borggraeve,

Affiliation Section of Molecular Design and Synthesis, Department of Chemistry, Heverlee, Belgium
⨯
Luc Leybaert,

Affiliation Department of Basic Medical Sciences, Physiology Group, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
⨯
David I. Yule,

Affiliation Department of Pharmacology & Physiology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Humbert De Smedt,

Affiliation Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven, Belgium
⨯
Jan B. Parys,

Affiliation Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven, Belgium
⨯
Geert Bultynck

* E-mail: Geert.Bultynck@med.kuleuven.be (GB); Giovanni.Monaco@med.kuleuven.be (GM)

Affiliation Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven, Belgium
⨯

Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP₃ Receptor

Giovanni Monaco,
Elke Decrock,
Koen Nuyts,
Larry E. Wagner II,
Tomas Luyten,
Sergei V. Strelkov,
Ludwig Missiaen,
Wim M. De Borggraeve,
Luc Leybaert,
David I. Yule

Published: August 30, 2013
https://doi.org/10.1371/journal.pone.0073386

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