Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells

• Laura M. Epple ,

  Contributed equally to this work with: Laura M. Epple, Rebecca D. Dodd

  Affiliations Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America, Cell and Molecular Biology Program, Cancer Biology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America

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• Rebecca D. Dodd ,

  Contributed equally to this work with: Laura M. Epple, Rebecca D. Dodd

  Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

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• Andrea L. Merz,

  Affiliation Cancer Center Metabolomics Core, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America

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• Anjelika M. Dechkovskaia,

  Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

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• Matthew Herring,

  Affiliation Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America

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• Benjamin A. Winston,

  Affiliation Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America

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• Alex M. Lencioni,

  Affiliation Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America

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• Rae L. Russell,

  Affiliation Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America

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• Helen Madsen,

  Affiliation Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America

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• Meheret Nega,

  Affiliation Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America

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• Nathaniel L. Dusto,

  Affiliation Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America

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• Jason White,

  Affiliation Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America

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• Darell D. Bigner,

  Affiliations Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America, Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina, United States of America

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• Christopher V. Nicchitta,

  Affiliation Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America

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• Natalie J. Serkova,

  Affiliations Cancer Center Metabolomics Core, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America, Department of Anesthesiology, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America

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•  [ ... ],
• Michael W. Graner

  * E-mail: michael.graner@ucdenver.edu

  Affiliation Cell and Molecular Biology Program, Cancer Biology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America

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