Endoplasmic Reticulum (ER) Stress Inducible Factor Cysteine-Rich with EGF-Like Domains 2 (Creld2) Is an Important Mediator of BMP9-Regulated Osteogenic Differentiation of Mesenchymal Stem Cells

Jiye Zhang; Yaguang Weng; Xing Liu; Jinhua Wang; Wenwen Zhang; Stephanie H. Kim; Hongyu Zhang; Ruidong Li; Yuhan Kong; Xiang Chen; Wei Shui; Ning Wang; Chen Zhao; Ningning Wu; Yunfeng He; Guoxin Nan; Xian Chen; Sheng Wen; Hongmei Zhang; Fang Deng; Lihua Wan; Hue H. Luu; Rex C. Haydon; Lewis L. Shi; Tong-Chuan He; Qiong Shi

doi:10.1371/journal.pone.0073086

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Research Article

Endoplasmic Reticulum (ER) Stress Inducible Factor Cysteine-Rich with EGF-Like Domains 2 (Creld2) Is an Important Mediator of BMP9-Regulated Osteogenic Differentiation of Mesenchymal Stem Cells

Jiye Zhang,

Affiliation Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
⨯
Yaguang Weng,

Affiliation Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
⨯
Xing Liu,

Affiliations Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics co-designated by Chinese Ministry of Education and Chongqing Bureau of Education, The Children’s Hospital of Chongqing Medical University, Chongqing, China
⨯
Jinhua Wang,

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Wenwen Zhang,

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Stephanie H. Kim,

Affiliation Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Hongyu Zhang,

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Ruidong Li,

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Yuhan Kong,

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Xiang Chen,

Affiliations Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Department of Orthopaedic Surgery, The Affiliated Tangdu Hospital of the Fourth Military Medical University, Xi’an, China
⨯
Wei Shui,

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Ning Wang,

Affiliations Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, School of Laboratory Medicine and the Affiliated Southwest Hospital of the Third Military Medical University, Chongqing, China
⨯
Chen Zhao,

Affiliations Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, School of Laboratory Medicine and the Affiliated Southwest Hospital of the Third Military Medical University, Chongqing, China
⨯
Ningning Wu,

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Yunfeng He,

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Guoxin Nan,

Affiliations Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics co-designated by Chinese Ministry of Education and Chongqing Bureau of Education, The Children’s Hospital of Chongqing Medical University, Chongqing, China
⨯
Xian Chen,

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Sheng Wen,

Affiliations Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics co-designated by Chinese Ministry of Education and Chongqing Bureau of Education, The Children’s Hospital of Chongqing Medical University, Chongqing, China
⨯
Hongmei Zhang,

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Fang Deng,

Affiliations Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America, School of Laboratory Medicine and the Affiliated Southwest Hospital of the Third Military Medical University, Chongqing, China
⨯
Lihua Wan,

Affiliation Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
⨯
Hue H. Luu,

Affiliation Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Rex C. Haydon,

Affiliation Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Lewis L. Shi,

Affiliation Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, Illinois, United States of America
⨯
Tong-Chuan He ,

* E-mail: tche@uchicago.edu (TCH); qiong.shi@yahoo.com (QS)

Affiliations Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China, Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics co-designated by Chinese Ministry of Education and Chongqing Bureau of Education, The Children’s Hospital of Chongqing Medical University, Chongqing, China
⨯
[ ... ],
Qiong Shi

* E-mail: tche@uchicago.edu (TCH); qiong.shi@yahoo.com (QS)

Affiliation Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing, China
⨯
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Endoplasmic Reticulum (ER) Stress Inducible Factor Cysteine-Rich with EGF-Like Domains 2 (Creld2) Is an Important Mediator of BMP9-Regulated Osteogenic Differentiation of Mesenchymal Stem Cells

Jiye Zhang,
Yaguang Weng,
Xing Liu,
Jinhua Wang,
Wenwen Zhang,
Stephanie H. Kim,
Hongyu Zhang,
Ruidong Li,
Yuhan Kong,
Xiang Chen

Published: September 3, 2013
https://doi.org/10.1371/journal.pone.0073086

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