Targeted Biomarker Discovery by High Throughput Glycosylation Profiling of Human Plasma Alpha1-Antitrypsin and Immunoglobulin A

L. Renee Ruhaak; Carolien A. M. Koeleman; Hae-Won Uh; Jord C. Stam; Diana van Heemst; Andrea B. Maier; Jeanine J. Houwing-Duistermaat; Paul J. Hensbergen; P. Eline Slagboom; André M. Deelder; Manfred Wuhrer

doi:10.1371/journal.pone.0073082

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Open Access

Peer-reviewed

Research Article

Targeted Biomarker Discovery by High Throughput Glycosylation Profiling of Human Plasma Alpha1-Antitrypsin and Immunoglobulin A

L. Renee Ruhaak ,

* E-mail: lrruhaak@gmail.com

Affiliation Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Carolien A. M. Koeleman,

Affiliation Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Hae-Won Uh,

Affiliation Section Medical Statistics, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Jord C. Stam,

Affiliation Section Biomolecular Imaging, Department of Biology, Utrecht University, Utrecht, The Netherlands
⨯
Diana van Heemst,

Affiliation Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Andrea B. Maier,

Affiliation Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Jeanine J. Houwing-Duistermaat,

Affiliation Section Medical Statistics, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Paul J. Hensbergen,

Affiliation Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
⨯
P. Eline Slagboom,

Affiliations Section Molecular Epidemiology, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium of Healthy Aging, Leiden, The Netherlands
⨯
André M. Deelder,

Affiliation Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Manfred Wuhrer

Affiliation Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
⨯

Targeted Biomarker Discovery by High Throughput Glycosylation Profiling of Human Plasma Alpha1-Antitrypsin and Immunoglobulin A

L. Renee Ruhaak,
Carolien A. M. Koeleman,
Hae-Won Uh,
Jord C. Stam,
Diana van Heemst,
Andrea B. Maier,
Jeanine J. Houwing-Duistermaat,
Paul J. Hensbergen,
P. Eline Slagboom,
André M. Deelder

Published: September 9, 2013
https://doi.org/10.1371/journal.pone.0073082

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Glycosylation
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Glycoproteins
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Blood plasma
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