IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation

Eleonora Olivotto; Miguel Otero; Annalisa Astolfi; Daniela Platano; Annalisa Facchini; Stefania Pagani; Flavio Flamigni; Andrea Facchini; Mary B. Goldring; Rosa Maria Borzì; Kenneth B. Marcu

doi:10.1371/journal.pone.0073024

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Peer-reviewed

Research Article

IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation

Eleonora Olivotto ,

Contributed equally to this work with: Eleonora Olivotto, Miguel Otero

Affiliation Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopedic Research Institute, Bologna, Italy
⨯
Miguel Otero ,

Contributed equally to this work with: Eleonora Olivotto, Miguel Otero

Affiliation Research Division, Hospital for Special Surgery and Weill Cornell Medical College, New York, New York, United States of America
⨯
Annalisa Astolfi,

Affiliation “G.Prodi” Cancer Research Center, University of Bologna, Bologna, Italy
⨯
Daniela Platano,

Affiliation Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopedic Research Institute, Bologna, Italy
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Annalisa Facchini,

Affiliations Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy, Biomedical and Neuromotor Sciences Department, University of Bologna, Bologna, Italy
⨯
Stefania Pagani,

Affiliation Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopedic Research Institute, Bologna, Italy
⨯
Flavio Flamigni,

Affiliation Biomedical and Neuromotor Sciences Department, University of Bologna, Bologna, Italy
⨯
Andrea Facchini,

Affiliations Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopedic Research Institute, Bologna, Italy, Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy
⨯
Mary B. Goldring,

Affiliation Research Division, Hospital for Special Surgery and Weill Cornell Medical College, New York, New York, United States of America
⨯
Rosa Maria Borzì,

Affiliation Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopedic Research Institute, Bologna, Italy
⨯
Kenneth B. Marcu

* E-mail: kenneth.marcu@stonybrook.edu

Affiliations Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopedic Research Institute, Bologna, Italy, Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, New York, United States of America
⨯

IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation

Eleonora Olivotto,
Miguel Otero,
Annalisa Astolfi,
Daniela Platano,
Annalisa Facchini,
Stefania Pagani,
Flavio Flamigni,
Andrea Facchini,
Mary B. Goldring,
Rosa Maria Borzì

Published: September 2, 2013
https://doi.org/10.1371/journal.pone.0073024

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Chondrocytes
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Cell differentiation
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Immunohistochemistry techniques
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Transcription factors
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Collagenases
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Cartilage
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