Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications

• Jose L. Ortega Roldan,

  Affiliations Departamento de Química Física e Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, Granada, Spain, Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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• Salvador Casares,

  Affiliation Departamento de Química Física e Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, Granada, Spain

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• Malene Ringkjøbing Jensen,

  Affiliation Protein Dynamics and Flexibility by NMR, Institut de Biologie Structurale Jean-Pierre Ebel, CEA, CNRS, UJF UMR 5075, Grenoble, France

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• Nayra Cárdenes,

  Affiliation Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Jerónimo Bravo,

  Affiliation Instituto de Biomedicina de Valencia, IBV-CSIC, Valencia, Spain

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• Martin Blackledge,

  Affiliation Protein Dynamics and Flexibility by NMR, Institut de Biologie Structurale Jean-Pierre Ebel, CEA, CNRS, UJF UMR 5075, Grenoble, France

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• Ana I. Azuaga ,

  * E-mail: aiazuaga@ugr.es (AIA); nvnuland@vub.ac.be (NAJvN)

  Affiliation Departamento de Química Física e Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, Granada, Spain

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• Nico A. J. van Nuland

  * E-mail: aiazuaga@ugr.es (AIA); nvnuland@vub.ac.be (NAJvN)

  Affiliations Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium, Department of Structural Biology, VIB, Brussels, Belgium

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