Mutagenic and Cytotoxic Properties of Oxidation Products of 5-Methylcytosine Revealed by Next-Generation Sequencing

Open Access

Peer-reviewed

Research Article

Xi-Wen Xing,

Affiliation Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, P.R. China
⨯
Yu-Li Liu,

Affiliation Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, P.R. China
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Mario Vargas,

Affiliation Department of Chemistry, University of California Riverside, Riverside, California, United States of America
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Yinsheng Wang,

Affiliation Department of Chemistry, University of California Riverside, Riverside, California, United States of America
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Yu-Qi Feng,

Affiliation Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, P.R. China
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Xiang Zhou ,

* E-mail: bfyuan@whu.edu.cn (BFY); xzhou@whu.edu.cn (XZ)

Affiliation Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, P.R. China
⨯
Bi-Feng Yuan

* E-mail: bfyuan@whu.edu.cn (BFY); xzhou@whu.edu.cn (XZ)

Affiliation Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, P.R. China
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Cytosine
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DNA replication
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Polymerase chain reaction
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Genomics
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DNA methylation
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Next-generation sequencing
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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
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Nucleobases
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