Myeloid Cells Expressing VEGF and Arginase-1 Following Uptake of Damaged Retinal Pigment Epithelium Suggests Potential Mechanism That Drives the Onset of Choroidal Angiogenesis in Mice

Jian Liu; David A. Copland; Shintaro Horie; Wei-Kang Wu; Mei Chen; Yunhe Xu; B. Paul Morgan; Matthias Mack; Heping Xu; Lindsay B. Nicholson; Andrew D. Dick

doi:10.1371/journal.pone.0072935

Loading metrics

Open Access

Peer-reviewed

Research Article

Myeloid Cells Expressing VEGF and Arginase-1 Following Uptake of Damaged Retinal Pigment Epithelium Suggests Potential Mechanism That Drives the Onset of Choroidal Angiogenesis in Mice

Jian Liu,

Affiliation Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
⨯
David A. Copland,

Affiliation Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
⨯
Shintaro Horie,

Affiliation Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
⨯
Wei-Kang Wu,

Affiliation Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
⨯
Mei Chen,

Affiliation Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom
⨯
Yunhe Xu,

Affiliation Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
⨯
B. Paul Morgan,

Affiliation School of Medicine, Cardiff University, Cardiff, United Kingdom
⨯
Matthias Mack,

Affiliation Department of Internal Medicine II, University Hospital, Regensburg, Regensburg, Germany
⨯
Heping Xu,

Affiliation Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom
⨯
Lindsay B. Nicholson,

Affiliations Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
⨯
Andrew D. Dick

* E-mail: a.dick@bristol.ac.uk

Affiliations Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
⨯

Myeloid Cells Expressing VEGF and Arginase-1 Following Uptake of Damaged Retinal Pigment Epithelium Suggests Potential Mechanism That Drives the Onset of Choroidal Angiogenesis in Mice

Jian Liu,
David A. Copland,
Shintaro Horie,
Wei-Kang Wu,
Mei Chen,
Yunhe Xu,
B. Paul Morgan,
Matthias Mack,
Heping Xu,
Lindsay B. Nicholson

Published: August 16, 2013
https://doi.org/10.1371/journal.pone.0072935

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Lasers
Is the Subject Area "Lasers" applicable to this article?

Thanks for your feedback.
Microglial cells
Is the Subject Area "Microglial cells" applicable to this article?

Thanks for your feedback.
Bone marrow cells
Is the Subject Area "Bone marrow cells" applicable to this article?

Thanks for your feedback.
Angiogenesis
Is the Subject Area "Angiogenesis" applicable to this article?

Thanks for your feedback.
Retina
Is the Subject Area "Retina" applicable to this article?

Thanks for your feedback.
Monocytes
Is the Subject Area "Monocytes" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.