Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells

Barbara Sigala; Chad McKee; Junpei Soeda; Valerio Pazienza; Maelle Morgan; Ching-I Lin; Clare Selden; Sara Vander Borght; Gianluigi Mazzoccoli; Tania Roskams; Manlio Vinciguerra; Jude A. Oben

doi:10.1371/journal.pone.0072928

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Peer-reviewed

Research Article

Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells

Barbara Sigala,

Affiliation Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London, United Kingdom
⨯
Chad McKee,

Affiliation Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London, United Kingdom
⨯
Junpei Soeda,

Affiliation Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London, United Kingdom
⨯
Valerio Pazienza,

Affiliation Gastroenterology Unit, IRCCS “Casa Sollievo della Sofferenza”, Hospital San Giovanni Rotondo (FG), San Giovanni, Italy
⨯
Maelle Morgan,

Affiliation Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London, United Kingdom
⨯
Ching-I Lin,

Affiliation Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London, United Kingdom
⨯
Clare Selden,

Affiliation Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London, United Kingdom
⨯
Sara Vander Borght,

Affiliation Department of Pathology, Laboratory of Morphology and Molecular Pathology, University Hospitals of Leuven, Leuven, Belgium
⨯
Gianluigi Mazzoccoli,

Affiliation Department of Medical Sciences, Division of Internal Medicine IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, San Giovanni Rotondo (FG), Italy
⨯
Tania Roskams,

Affiliation Department of Pathology, Laboratory of Morphology and Molecular Pathology, University Hospitals of Leuven, Leuven, Belgium
⨯
Manlio Vinciguerra ,

* E-mail: j.oben@ucl.ac.uk (JAO); m.vinciguerra@ucl.ac.uk (MV)

Affiliations Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London, United Kingdom, Gastroenterology Unit, IRCCS “Casa Sollievo della Sofferenza”, Hospital San Giovanni Rotondo (FG), San Giovanni, Italy
⨯
Jude A. Oben

* E-mail: j.oben@ucl.ac.uk (JAO); m.vinciguerra@ucl.ac.uk (MV)

Affiliations Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London, United Kingdom, Department of Gastroenterology and Hepatology, Guy's and St Thomas' Hospital, London, United Kingdom
⨯

Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells

Barbara Sigala,
Chad McKee,
Junpei Soeda,
Valerio Pazienza,
Maelle Morgan,
Ching-I Lin,
Clare Selden,
Sara Vander Borght,
Gianluigi Mazzoccoli,
Tania Roskams

Published: September 3, 2013
https://doi.org/10.1371/journal.pone.0072928

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