Immunization against GAD Induces Antibody Binding to GAD-Independent Antigens and Brainstem GABAergic Neuronal Loss

Thashi Chang; Harry Alexopoulos; Philippa Pettingill; Mary McMenamin; Robert Deacon; Ferenc Erdelyi; Gabor Szabó; Camilla J. Buckley; Angela Vincent

doi:10.1371/journal.pone.0072921

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Open Access

Peer-reviewed

Research Article

Immunization against GAD Induces Antibody Binding to GAD-Independent Antigens and Brainstem GABAergic Neuronal Loss

Thashi Chang,

Affiliations Neuroimmunology Group, Weatherall Institute of Molecular Medicine and Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka
⨯
Harry Alexopoulos,

Affiliation Neuroimmunology Group, Weatherall Institute of Molecular Medicine and Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
⨯
Philippa Pettingill,

Affiliation Neuroimmunology Group, Weatherall Institute of Molecular Medicine and Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
⨯
Mary McMenamin,

Affiliation Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
⨯
Robert Deacon,

Affiliation Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
⨯
Ferenc Erdelyi,

Affiliation Department of Gene Technology and Developmental Neurobiology, Institute of Experimental Medicine, Budapest, Hungary
⨯
Gabor Szabó,

Affiliation Department of Gene Technology and Developmental Neurobiology, Institute of Experimental Medicine, Budapest, Hungary
⨯
Camilla J. Buckley,

Affiliation Neuroimmunology Group, Weatherall Institute of Molecular Medicine and Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
⨯
Angela Vincent

* E-mail: angela.vincent@ndcn.ox.ac.uk

Affiliation Neuroimmunology Group, Weatherall Institute of Molecular Medicine and Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
⨯

Immunization against GAD Induces Antibody Binding to GAD-Independent Antigens and Brainstem GABAergic Neuronal Loss

Thashi Chang,
Harry Alexopoulos,
Philippa Pettingill,
Mary McMenamin,
Robert Deacon,
Ferenc Erdelyi,
Gabor Szabó,
Camilla J. Buckley,
Angela Vincent

Published: September 18, 2013
https://doi.org/10.1371/journal.pone.0072921

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