Interferon and Ribavirin Combination Treatment Synergistically Inhibit HCV Internal Ribosome Entry Site Mediated Translation at the Level of Polyribosome Formation

Rajesh Panigrahi; Sidhartha Hazari; Sruti Chandra; Partha K. Chandra; Sibnarayan Datta; Ramazan Kurt; Craig E. Cameron; Zhuhui Huang; Haitao Zhang; Robert F. Garry; Luis A. Balart; Srikanta Dash

doi:10.1371/journal.pone.0072791

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Open Access

Peer-reviewed

Research Article

Interferon and Ribavirin Combination Treatment Synergistically Inhibit HCV Internal Ribosome Entry Site Mediated Translation at the Level of Polyribosome Formation

Rajesh Panigrahi,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Sidhartha Hazari,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Sruti Chandra,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Partha K. Chandra,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Sibnarayan Datta,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Ramazan Kurt,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Craig E. Cameron,

Affiliation Department of Biochemistry and Molecular Biology, Penn State University, University Park, United States of America
⨯
Zhuhui Huang,

Affiliation Hepatitis Research Program, Southern Research Institute, Frederick, Maryland, United States of America
⨯
Haitao Zhang,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Robert F. Garry,

Affiliation Micribiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
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Luis A. Balart,

Affiliation Gastroenterology, Hepatology and Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Srikanta Dash

* E-mail: sdash@tulane.edu

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
⨯

Interferon and Ribavirin Combination Treatment Synergistically Inhibit HCV Internal Ribosome Entry Site Mediated Translation at the Level of Polyribosome Formation

Rajesh Panigrahi,
Sidhartha Hazari,
Sruti Chandra,
Partha K. Chandra,
Sibnarayan Datta,
Ramazan Kurt,
Craig E. Cameron,
Zhuhui Huang,
Haitao Zhang,
Robert F. Garry

Published: August 23, 2013
https://doi.org/10.1371/journal.pone.0072791

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Polyribosomes
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Internal ribosome entry site
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Protein translation
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