DNA-PKcs Inhibition Sensitizes Cancer Cells to Carbon-Ion Irradiation via Telomere Capping Disruption

Xin Zhou; Xin Zhang; Yi Xie; Kaoru Tanaka; Bing Wang; Hong Zhang

doi:10.1371/journal.pone.0072641

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Open Access

Peer-reviewed

Research Article

DNA-PKcs Inhibition Sensitizes Cancer Cells to Carbon-Ion Irradiation via Telomere Capping Disruption

Xin Zhou,

Affiliations Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China, Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China, Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou, China
⨯
Xin Zhang,

Affiliations Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China, Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China, Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou, China
⨯
Yi Xie,

Affiliations Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China, Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China, Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou, China
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Kaoru Tanaka,

Affiliation Radiation Risk Reduction Research Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Inage-ku, Chiba, Japan
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Bing Wang,

Affiliation Radiation Risk Reduction Research Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Inage-ku, Chiba, Japan
⨯
Hong Zhang

* E-mail: zhangh@impcas.ac.cn

Affiliations Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China, Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China, Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou, China
⨯

DNA-PKcs Inhibition Sensitizes Cancer Cells to Carbon-Ion Irradiation via Telomere Capping Disruption

Xin Zhou,
Xin Zhang,
Yi Xie,
Kaoru Tanaka,
Bing Wang,
Hong Zhang

Published: August 27, 2013
https://doi.org/10.1371/journal.pone.0072641

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Telomeres
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DNA repair
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DNA damage
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HeLa cells
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Telomere length
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Apoptosis
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Polymerase chain reaction
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Non-homologous end joining
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