Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model

Laetitia Aerts; Marie-Ève Hamelin; Chantal Rhéaume; Sophie Lavigne; Christian Couture; WooJin Kim; Delia Susan-Resiga; Annik Prat; Nabil G. Seidah; Nathalie Vergnolle; Beatrice Riteau; Guy Boivin

doi:10.1371/journal.pone.0072529

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Open Access

Peer-reviewed

Research Article

Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model

Laetitia Aerts,

Affiliation Centre de Recherche en Infectiologie du Centre Hospitalier Universitaire de Québec and Université Laval, Quebec, Canada
⨯
Marie-Ève Hamelin,

Affiliation Centre de Recherche en Infectiologie du Centre Hospitalier Universitaire de Québec and Université Laval, Quebec, Canada
⨯
Chantal Rhéaume,

Affiliation Centre de Recherche en Infectiologie du Centre Hospitalier Universitaire de Québec and Université Laval, Quebec, Canada
⨯
Sophie Lavigne,

Affiliation Department of Anatomo-pathology, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec, Canada
⨯
Christian Couture,

Affiliation Department of Anatomo-pathology, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec, Canada
⨯
WooJin Kim,

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Canada
⨯
Delia Susan-Resiga,

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Canada
⨯
Annik Prat,

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Canada
⨯
Nabil G. Seidah,

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Canada
⨯
Nathalie Vergnolle,

Affiliations Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France, Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada
⨯
Beatrice Riteau,

Affiliations Virologie et Pathologie Humaine, Université Lyon1, Faculté de Médecine RTH Laennec, Lyon, France, Centre de Tours-Nouzilly Institut National de la Recherche Agronomique, Nouzilly, France
⨯
Guy Boivin

* E-mail: Guy.Boivin@crchul.ulaval.ca

Affiliation Centre de Recherche en Infectiologie du Centre Hospitalier Universitaire de Québec and Université Laval, Quebec, Canada
⨯

Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model

Laetitia Aerts,
Marie-Ève Hamelin,
Chantal Rhéaume,
Sophie Lavigne,
Christian Couture,
WooJin Kim,
Delia Susan-Resiga,
Annik Prat,
Nabil G. Seidah,
Nathalie Vergnolle

Published: August 28, 2013
https://doi.org/10.1371/journal.pone.0072529

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