Epigenetic Regulation of Pluripotent Genes Mediates Stem Cell Features in Human Hepatocellular Carcinoma and Cancer Cell Lines

Xiao Qi Wang; Ray Kit Ng; Xiaoyan Ming; Wu Zhang; Lin Chen; Andrew C. Y. Chu; Roberta Pang; Chung Mau Lo; Sai Wah Tsao; Xuqing Liu; Ronnie T. P. Poon; Sheung Tat Fan

doi:10.1371/journal.pone.0072435

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Open Access

Peer-reviewed

Research Article

Epigenetic Regulation of Pluripotent Genes Mediates Stem Cell Features in Human Hepatocellular Carcinoma and Cancer Cell Lines

Xiao Qi Wang ,

Contributed equally to this work with: Xiao Qi Wang, Ray Kit Ng

Affiliations Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China, State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Ray Kit Ng ,

Contributed equally to this work with: Xiao Qi Wang, Ray Kit Ng

Affiliations Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China, Center for Reproduction, Development and Growth, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Xiaoyan Ming,

Affiliation Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Wu Zhang,

Affiliation Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Lin Chen,

Affiliation Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Andrew C. Y. Chu,

Affiliation Center for Cancer Research, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Roberta Pang,

Affiliation Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Chung Mau Lo,

Affiliation Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Sai Wah Tsao,

Affiliation Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Xuqing Liu,

Affiliation Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Ronnie T. P. Poon,

Affiliations Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China, State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯
Sheung Tat Fan

* E-mail: stfan@hku.hk

Affiliations Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China, State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
⨯

Epigenetic Regulation of Pluripotent Genes Mediates Stem Cell Features in Human Hepatocellular Carcinoma and Cancer Cell Lines

Xiao Qi Wang,
Ray Kit Ng,
Xiaoyan Ming,
Wu Zhang,
Lin Chen,
Andrew C. Y. Chu,
Roberta Pang,
Chung Mau Lo,
Sai Wah Tsao,
Xuqing Liu

Published: September 4, 2013
https://doi.org/10.1371/journal.pone.0072435

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DNA methylation
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Hepatocellular carcinoma
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Lung and intrathoracic tumors
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Pluripotency
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Epigenetics
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Gene expression
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Metastasis
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Cancers and neoplasms
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