MicroRNA-34a Mediates the Autocrine Signaling of PAR2-Activating Proteinase and Its Role in Colonic Cancer Cell Proliferation

Yiming Ma; Wuyun Bao-Han; Xue Lv; Yuntao Su; Xinhua Zhao; Yongmei Yin; Xingmao Zhang; Zhixiang Zhou; Wallace K. MacNaughton; Hongying Wang

doi:10.1371/journal.pone.0072383

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Open Access

Peer-reviewed

Research Article

MicroRNA-34a Mediates the Autocrine Signaling of PAR₂-Activating Proteinase and Its Role in Colonic Cancer Cell Proliferation

Yiming Ma,

Affiliation State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
⨯
Wuyun Bao-Han,

Affiliation State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
⨯
Xue Lv,

Affiliation State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
⨯
Yuntao Su,

Affiliation First affiliated Hospital of Nanjing Medical University, Nanjing, PR China
⨯
Xinhua Zhao,

Affiliation State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
⨯
Yongmei Yin,

Affiliation First affiliated Hospital of Nanjing Medical University, Nanjing, PR China
⨯
Xingmao Zhang,

Affiliation Department of gastrointestinal cancer surgery, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
⨯
Zhixiang Zhou,

Affiliation Department of gastrointestinal cancer surgery, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
⨯
Wallace K. MacNaughton,

Affiliations Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
⨯
Hongying Wang

* E-mail: hongyingwang@cicams.ac.cn

Affiliation State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
⨯

MicroRNA-34a Mediates the Autocrine Signaling of PAR₂-Activating Proteinase and Its Role in Colonic Cancer Cell Proliferation

Yiming Ma,
Wuyun Bao-Han,
Xue Lv,
Yuntao Su,
Xinhua Zhao,
Yongmei Yin,
Xingmao Zhang,
Zhixiang Zhou,
Wallace K. MacNaughton,
Hongying Wang

Published: August 26, 2013
https://doi.org/10.1371/journal.pone.0072383

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