RasGRPs Are Targets of the Anti-Cancer Agent Ingenol-3-Angelate

Xiaohua Song; Ana Lopez-Campistrous; Lucy Sun; Nancy A. Dower; Noemi Kedei; Jing Yang; Jessica S. Kelsey; Nancy E. Lewin; Tim E. Esch; Peter M. Blumberg; James C. Stone

doi:10.1371/journal.pone.0072331

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Open Access

Peer-reviewed

Research Article

RasGRPs Are Targets of the Anti-Cancer Agent Ingenol-3-Angelate

Xiaohua Song,

Affiliation Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
⨯
Ana Lopez-Campistrous,

Affiliation Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
⨯
Lucy Sun,

Affiliation Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
⨯
Nancy A. Dower,

Affiliation Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
⨯
Noemi Kedei,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jing Yang,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jessica S. Kelsey,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Nancy E. Lewin,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Tim E. Esch,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Peter M. Blumberg,

Affiliation Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
James C. Stone

* E-mail: jim.stone@ualberta.ca

Affiliation Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
⨯

RasGRPs Are Targets of the Anti-Cancer Agent Ingenol-3-Angelate

Xiaohua Song,
Ana Lopez-Campistrous,
Lucy Sun,
Nancy A. Dower,
Noemi Kedei,
Jing Yang,
Jessica S. Kelsey,
Nancy E. Lewin,
Tim E. Esch,
Peter M. Blumberg

Published: August 21, 2013
https://doi.org/10.1371/journal.pone.0072331

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