Repressive Effect of Primary Virus Replication on Superinfection Correlated with Gut-Derived Central Memory CD4+ T Cells in SHIV-Infected Chinese Rhesus Macaques

Jing Xue; Zhe Cong; Jing Xiong; Wei Wang; Hong Jiang; Ting Chen; Fangxin Wu; Kejian Liu; Aihua Su; Bin Ju; Zhiwei Chen; Marcelo A. Couto; Qiang Wei; Chuan Qin

doi:10.1371/journal.pone.0072295

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Open Access

Peer-reviewed

Research Article

Repressive Effect of Primary Virus Replication on Superinfection Correlated with Gut-Derived Central Memory CD4⁺ T Cells in SHIV-Infected Chinese Rhesus Macaques

Jing Xue ,

Contributed equally to this work with: Jing Xue, Zhe Cong

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Zhe Cong ,

Contributed equally to this work with: Jing Xue, Zhe Cong

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Jing Xiong,

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Wei Wang,

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Hong Jiang,

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Ting Chen,

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Fangxin Wu,

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Kejian Liu,

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Aihua Su,

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Bin Ju,

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Zhiwei Chen,

Affiliation AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
⨯
Marcelo A. Couto,

Affiliation Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
⨯
Qiang Wei ,

* E-mail: weiqiang@cnilas.pumc.edu.cn (QW); qinchuan@pumc.edu.cn (CQ)

Current address: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, No 5 Panjiayuan Nanli, Chaoyang District, Beijing, China

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯
Chuan Qin

* E-mail: weiqiang@cnilas.pumc.edu.cn (QW); qinchuan@pumc.edu.cn (CQ)

Affiliation Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China
⨯

Repressive Effect of Primary Virus Replication on Superinfection Correlated with Gut-Derived Central Memory CD4⁺ T Cells in SHIV-Infected Chinese Rhesus Macaques

Jing Xue,
Zhe Cong,
Jing Xiong,
Wei Wang,
Hong Jiang,
Ting Chen,
Fangxin Wu,
Kejian Liu,
Aihua Su,
Bin Ju

Published: September 2, 2013
https://doi.org/10.1371/journal.pone.0072295

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