Multimodal MRI and 31P-MRS Investigations of the ACTA1(Asp286Gly) Mouse Model of Nemaline Myopathy Provide Evidence of Impaired In Vivo Muscle Function, Altered Muscle Structure and Disturbed Energy Metabolism

Charlotte Gineste; Guillaume Duhamel; Yann Le Fur; Christophe Vilmen; Patrick J. Cozzone; Kristen J. Nowak; David Bendahan; Julien Gondin

doi:10.1371/journal.pone.0072294

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Peer-reviewed

Research Article

Multimodal MRI and ³¹P-MRS Investigations of the ACTA1(Asp286Gly) Mouse Model of Nemaline Myopathy Provide Evidence of Impaired In Vivo Muscle Function, Altered Muscle Structure and Disturbed Energy Metabolism

Charlotte Gineste,

Affiliation Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), Centre de Résonance Magnétique Biologique et Médicale (CRMBM) Unité Mixte de Recherche (UMR) 7339, Marseille, France
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Guillaume Duhamel,

Affiliation Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), Centre de Résonance Magnétique Biologique et Médicale (CRMBM) Unité Mixte de Recherche (UMR) 7339, Marseille, France
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Yann Le Fur,

Affiliation Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), Centre de Résonance Magnétique Biologique et Médicale (CRMBM) Unité Mixte de Recherche (UMR) 7339, Marseille, France
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Christophe Vilmen,

Affiliation Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), Centre de Résonance Magnétique Biologique et Médicale (CRMBM) Unité Mixte de Recherche (UMR) 7339, Marseille, France
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Patrick J. Cozzone,

Affiliation Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), Centre de Résonance Magnétique Biologique et Médicale (CRMBM) Unité Mixte de Recherche (UMR) 7339, Marseille, France
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Kristen J. Nowak,

Affiliation University of Western Australia, Centre for Medical Research, Western Australian Institute for Medical Research (WAIMR), Nedlands, Australia
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David Bendahan,

Affiliation Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), Centre de Résonance Magnétique Biologique et Médicale (CRMBM) Unité Mixte de Recherche (UMR) 7339, Marseille, France
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Julien Gondin

* E-mail: julien.gondin@univ-amu.fr

Affiliation Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), Centre de Résonance Magnétique Biologique et Médicale (CRMBM) Unité Mixte de Recherche (UMR) 7339, Marseille, France
⨯

Multimodal MRI and ³¹P-MRS Investigations of the ACTA1(Asp286Gly) Mouse Model of Nemaline Myopathy Provide Evidence of Impaired In Vivo Muscle Function, Altered Muscle Structure and Disturbed Energy Metabolism

Charlotte Gineste,
Guillaume Duhamel,
Yann Le Fur,
Christophe Vilmen,
Patrick J. Cozzone,
Kristen J. Nowak,
David Bendahan,
Julien Gondin

Published: August 20, 2013
https://doi.org/10.1371/journal.pone.0072294

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