IFN-γ-Stimulated Neutrophils Suppress Lymphocyte Proliferation through Expression of PD-L1

Stan de Kleijn; Jeroen D. Langereis; Jenneke Leentjens; Matthijs Kox; Mihai G. Netea; Leo Koenderman; Gerben Ferwerda; Peter Pickkers; Peter W. M. Hermans

doi:10.1371/journal.pone.0072249

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Peer-reviewed

Research Article

IFN-γ-Stimulated Neutrophils Suppress Lymphocyte Proliferation through Expression of PD-L1

Stan de Kleijn ,

Contributed equally to this work with: Stan de Kleijn, Jeroen D. Langereis

Affiliation Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Jeroen D. Langereis ,

Contributed equally to this work with: Stan de Kleijn, Jeroen D. Langereis

* E-mail: j.langereis@cukz.umcn.nl

Affiliation Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Jenneke Leentjens,

Affiliations Department of Intensive Care Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Matthijs Kox,

Affiliations Department of Intensive Care Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands, Department of Anesthesiology, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Mihai G. Netea,

Affiliation Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Leo Koenderman,

Affiliation Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Gerben Ferwerda,

Affiliation Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Peter Pickkers,

Affiliation Department of Intensive Care Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Peter W. M. Hermans

Affiliation Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯

IFN-γ-Stimulated Neutrophils Suppress Lymphocyte Proliferation through Expression of PD-L1

Stan de Kleijn,
Jeroen D. Langereis,
Jenneke Leentjens,
Matthijs Kox,
Mihai G. Netea,
Leo Koenderman,
Gerben Ferwerda,
Peter Pickkers,
Peter W. M. Hermans

Published: August 28, 2013
https://doi.org/10.1371/journal.pone.0072249

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Neutrophils
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Lymphocyte proliferation
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Lymphocytes
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Gene expression
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Endotoxemia
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