Metabolic Reprogramming for Producing Energy and Reducing Power in Fumarate Hydratase Null Cells from Hereditary Leiomyomatosis Renal Cell Carcinoma

• Youfeng Yang ,

  Contributed equally to this work with: Youfeng Yang, Andrew N. Lane

  Affiliation Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Andrew N. Lane ,

  Contributed equally to this work with: Youfeng Yang, Andrew N. Lane

  Affiliations J.G. Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America, Center for Regulatory and Environmental Analytical Metabolomics (CREAM), University of Louisville, Louisville, Kentucky, United States of America

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• Christopher J. Ricketts,

  Affiliation Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Carole Sourbier,

  Affiliation Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Ming-Hui Wei,

  Affiliation Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Brian Shuch,

  Affiliation Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Lisa Pike,

  Affiliation Seahorse Bioscience, North Billerica, Massachusetts, United States of America

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• Min Wu,

  Current address: Center for Human Genetic Research, Richard B. Simches Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  Affiliation Seahorse Bioscience, North Billerica, Massachusetts, United States of America

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• Tracey A. Rouault,

  Affiliation Molecular Medicine Program, Eunice Kennedy Shriver National Institutes of Child Health and Development, Bethesda, Maryland, United States of America

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• Laszlo G. Boros,

  Affiliations SIDMAP LLC, Los Angeles, California, United States of America, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America

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• Teresa W.-M. Fan ,

  * E-mail: WML@nih.gov (WML); twmfan@gmail.com (TWMF)

  Affiliations J.G. Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America, Center for Regulatory and Environmental Analytical Metabolomics (CREAM), University of Louisville, Louisville, Kentucky, United States of America, Department of Chemistry, University of Louisville, Louisville, Kentucky, United States of America

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• W. Marston Linehan

  * E-mail: WML@nih.gov (WML); twmfan@gmail.com (TWMF)

  Affiliation Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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