Reduced Expression of Enac in Placenta Tissues of Patients with Severe Preeclampsia Is Related to Compromised Trophoblastic Cell Migration and Invasion during Pregnancy

Shan Wang; Guolin He; Yue Yang; Ying Liu; Ruiying Diao; Kai Sheng; Xinghui Liu; Wenming Xu

doi:10.1371/journal.pone.0072153

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Open Access

Peer-reviewed

Research Article

Reduced Expression of Enac in Placenta Tissues of Patients with Severe Preeclampsia Is Related to Compromised Trophoblastic Cell Migration and Invasion during Pregnancy

Shan Wang ,

Contributed equally to this work with: Shan Wang, Guolin He

Affiliations Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China, Joint Laboratory of Reproductive Medicine, Sichuan University-The Chinese University of Hong Kong, West China Second University Hospital, Sichuan University, Chengdu, China, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
⨯
Guolin He ,

Contributed equally to this work with: Shan Wang, Guolin He

Affiliations Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China, Joint Laboratory of Reproductive Medicine, Sichuan University-The Chinese University of Hong Kong, West China Second University Hospital, Sichuan University, Chengdu, China
⨯
Yue Yang,

Affiliations Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China, Joint Laboratory of Reproductive Medicine, Sichuan University-The Chinese University of Hong Kong, West China Second University Hospital, Sichuan University, Chengdu, China
⨯
Ying Liu,

Affiliation Joint Laboratory of Reproductive Medicine, Sichuan University-The Chinese University of Hong Kong, West China Second University Hospital, Sichuan University, Chengdu, China
⨯
Ruiying Diao,

Affiliation Shenzhen Key Lab of Male Reproduction and Genetics, Peking University Shenzhen Hospital, Shenzhen, PR China
⨯
Kai Sheng,

Affiliations Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China, Joint Laboratory of Reproductive Medicine, Sichuan University-The Chinese University of Hong Kong, West China Second University Hospital, Sichuan University, Chengdu, China
⨯
Xinghui Liu ,

* E-mail: xinghuiliu@163.com (XL); wenmingx@gmail.com (WX)

Affiliation Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China
⨯
Wenming Xu

* E-mail: xinghuiliu@163.com (XL); wenmingx@gmail.com (WX)

Affiliations Joint Laboratory of Reproductive Medicine, Sichuan University-The Chinese University of Hong Kong, West China Second University Hospital, Sichuan University, Chengdu, China, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
⨯

Reduced Expression of Enac in Placenta Tissues of Patients with Severe Preeclampsia Is Related to Compromised Trophoblastic Cell Migration and Invasion during Pregnancy

Shan Wang,
Guolin He,
Yue Yang,
Ying Liu,
Ruiying Diao,
Kai Sheng,
Xinghui Liu,
Wenming Xu

Published: August 19, 2013
https://doi.org/10.1371/journal.pone.0072153

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Preeclampsia
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Placenta
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Pregnancy
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Small interfering RNA
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Cell migration
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