S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB1

Open Access

Peer-reviewed

Research Article

S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB¹

Jean-Christophe Simard,

Affiliation Laboratoire de Recherche en Inflammation des Granulocytes, Université du Québec Institut National de la Recherche Scientifique, Institut Armand-Frappier, Laval, Québec, Canada
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Annabelle Cesaro,

Affiliation Axe Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec and Faculté de Médecine, Université Laval, Québec, Canada
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Julie Chapeton-Montes,

Affiliation Axe Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec and Faculté de Médecine, Université Laval, Québec, Canada
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Mélanie Tardif,

Affiliation Axe Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec and Faculté de Médecine, Université Laval, Québec, Canada
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Francis Antoine,

Affiliation Laboratoire de Recherche en Inflammation des Granulocytes, Université du Québec Institut National de la Recherche Scientifique, Institut Armand-Frappier, Laval, Québec, Canada
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Denis Girard,

Affiliation Laboratoire de Recherche en Inflammation des Granulocytes, Université du Québec Institut National de la Recherche Scientifique, Institut Armand-Frappier, Laval, Québec, Canada
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Philippe A. Tessier

* E-mail: Philippe.Tessier@crchul.ulaval.ca

Affiliation Axe Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec and Faculté de Médecine, Université Laval, Québec, Canada
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Transcription factors
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Secretion
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Cytokines
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Inflammasomes
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Enzyme-linked immunoassays
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Monocytes
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Immune receptor signaling
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Small interfering RNA
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