Protective Effects of Metallothionein on Isoniazid and Rifampicin-Induced Hepatotoxicity in Mice

Yong Lian; Jing Zhao; Peiyu Xu; Yimei Wang; Jun Zhao; Li Jia; Ze Fu; Li Jing; Gang Liu; Shuangqing Peng

doi:10.1371/journal.pone.0072058

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Open Access

Peer-reviewed

Research Article

Protective Effects of Metallothionein on Isoniazid and Rifampicin-Induced Hepatotoxicity in Mice

Yong Lian ,

Contributed equally to this work with: Yong Lian, Jing Zhao

Affiliations Evaluation and Research Centre for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China, Department of Toxicology, West China School of Public Health, Sichuan University, Chengdu, China
⨯
Jing Zhao ,

Contributed equally to this work with: Yong Lian, Jing Zhao

Affiliation Evaluation and Research Centre for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China
⨯
Peiyu Xu,

Affiliation Department of Toxicology, West China School of Public Health, Sichuan University, Chengdu, China
⨯
Yimei Wang ,

* E-mail: pengsq@hotmail.com (SP); wangyimei2006@126.com (YW)

Affiliation Evaluation and Research Centre for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China
⨯
Jun Zhao,

Affiliation Evaluation and Research Centre for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China
⨯
Li Jia,

Affiliation Evaluation and Research Centre for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China
⨯
Ze Fu,

Affiliation Evaluation and Research Centre for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China
⨯
Li Jing,

Affiliation Evaluation and Research Centre for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China
⨯
Gang Liu,

Affiliation Evaluation and Research Centre for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China
⨯
Shuangqing Peng

* E-mail: pengsq@hotmail.com (SP); wangyimei2006@126.com (YW)

Affiliation Evaluation and Research Centre for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China
⨯

Protective Effects of Metallothionein on Isoniazid and Rifampicin-Induced Hepatotoxicity in Mice

Yong Lian,
Jing Zhao,
Peiyu Xu,
Yimei Wang,
Jun Zhao,
Li Jia,
Ze Fu,
Li Jing,
Gang Liu,
Shuangqing Peng

Published: August 13, 2013
https://doi.org/10.1371/journal.pone.0072058

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