A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1

Johannes S. Gach; Heribert Quendler; Tommy Tong; Kristin M. Narayan; Sean X. Du; Robert G. Whalen; James M. Binley; Donald N. Forthal; Pascal Poignard; Michael B. Zwick

doi:10.1371/journal.pone.0072054

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Open Access

Peer-reviewed

Research Article

A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1

Johannes S. Gach ,

Contributed equally to this work with: Johannes S. Gach, Heribert Quendler

* E-mail: jgach@uci.edu (JSG); zwick@scripps.edu (MBZ)

Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, Division of Infectious Diseases, University of California Irvine, Irvine, California, United States of America
⨯
Heribert Quendler ,

Contributed equally to this work with: Johannes S. Gach, Heribert Quendler

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Tommy Tong,

Affiliation Torrey Pines Institute for Molecular Studies, San Diego, California, United States of America
⨯
Kristin M. Narayan,

Affiliation Altravax, Inc., Sunnyvale, California, United States of America
⨯
Sean X. Du,

Affiliation Altravax, Inc., Sunnyvale, California, United States of America
⨯
Robert G. Whalen,

Affiliation Altravax, Inc., Sunnyvale, California, United States of America
⨯
James M. Binley,

Affiliation Torrey Pines Institute for Molecular Studies, San Diego, California, United States of America
⨯
Donald N. Forthal,

Affiliation Division of Infectious Diseases, University of California Irvine, Irvine, California, United States of America
⨯
Pascal Poignard,

Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Michael B. Zwick

* E-mail: jgach@uci.edu (JSG); zwick@scripps.edu (MBZ)

Affiliation Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
⨯

A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1

Johannes S. Gach,
Heribert Quendler,
Tommy Tong,
Kristin M. Narayan,
Sean X. Du,
Robert G. Whalen,
James M. Binley,
Donald N. Forthal,
Pascal Poignard,
Michael B. Zwick

Published: August 26, 2013
https://doi.org/10.1371/journal.pone.0072054

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