Model Free Approach to Kinetic Analysis of Real-Time Hyperpolarized 13C Magnetic Resonance Spectroscopy Data

Deborah K. Hill; Matthew R. Orton; Erika Mariotti; Jessica K. R. Boult; Rafal Panek; Maysam Jafar; Harold G. Parkes; Yann Jamin; Maria Falck Miniotis; Nada M. S. Al-Saffar; Mounia Beloueche-Babari; Simon P. Robinson; Martin O. Leach; Yuen-Li Chung; Thomas R. Eykyn

doi:10.1371/journal.pone.0071996

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Research Article

Model Free Approach to Kinetic Analysis of Real-Time Hyperpolarized ¹³C Magnetic Resonance Spectroscopy Data

Deborah K. Hill ,

Contributed equally to this work with: Deborah K. Hill, Matthew R. Orton

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Matthew R. Orton ,

Contributed equally to this work with: Deborah K. Hill, Matthew R. Orton

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Erika Mariotti,

Affiliation Division of Imaging Sciences and Biomedical Engineering, Kings College London, St. Thomas Hospital, London, United Kingdom
⨯
Jessica K. R. Boult,

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Rafal Panek,

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Maysam Jafar,

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Harold G. Parkes,

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Yann Jamin,

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Maria Falck Miniotis,

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Nada M. S. Al-Saffar,

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Mounia Beloueche-Babari,

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Simon P. Robinson,

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Martin O. Leach ,

* E-mail: martin.leach@icr.ac.uk (ML); thomas.eykyn@icr.ac.uk (TRE)

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Yuen-Li Chung,

Affiliation Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
⨯
Thomas R. Eykyn

* E-mail: martin.leach@icr.ac.uk (ML); thomas.eykyn@icr.ac.uk (TRE)

Affiliations Cancer Research UK (CR-UK) and Engineering and Physical Sciences Research Council (EPSRC) Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom, Division of Imaging Sciences and Biomedical Engineering, Kings College London, St. Thomas Hospital, London, United Kingdom
⨯

Model Free Approach to Kinetic Analysis of Real-Time Hyperpolarized ¹³C Magnetic Resonance Spectroscopy Data

Deborah K. Hill,
Matthew R. Orton,
Erika Mariotti,
Jessica K. R. Boult,
Rafal Panek,
Maysam Jafar,
Harold G. Parkes,
Yann Jamin,
Maria Falck Miniotis,
Nada M. S. Al-Saffar

Published: September 4, 2013
https://doi.org/10.1371/journal.pone.0071996

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