The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist

Catherine E. Erickson; Rukhsana Gul; Christopher P. Blessing; Jenny Nguyen; Tammy Liu; Lakshmi Pulakat; Murat Bastepe; Edwin K. Jackson; Bradley T. Andresen

doi:10.1371/journal.pone.0071980

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Peer-reviewed

Research Article

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist

Catherine E. Erickson ,

Contributed equally to this work with: Catherine E. Erickson, Rukhsana Gul

Affiliations Department of Internal Medicine, University of Missouri, Columbia, Missouri, United States of America, Harry S Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States of America
⨯
Rukhsana Gul ,

Contributed equally to this work with: Catherine E. Erickson, Rukhsana Gul

Affiliations Department of Internal Medicine, University of Missouri, Columbia, Missouri, United States of America, Harry S Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States of America, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia
⨯
Christopher P. Blessing,

Affiliation Department of Internal Medicine, University of Missouri, Columbia, Missouri, United States of America
⨯
Jenny Nguyen,

Affiliation Department of Pharmaceutical Sciences, Western University of Health Sciences, Pomona, California, United States of America
⨯
Tammy Liu,

Affiliation Department of Pharmaceutical Sciences, Western University of Health Sciences, Pomona, California, United States of America
⨯
Lakshmi Pulakat,

Affiliations Department of Internal Medicine, University of Missouri, Columbia, Missouri, United States of America, Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States of America, Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States of America, Harry S Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States of America
⨯
Murat Bastepe,

Affiliation Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Edwin K. Jackson,

Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh Pennsylvania, United States of America
⨯
Bradley T. Andresen

* E-mail: bandresen@westernu.edu

Affiliations Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States of America, Department of Pharmaceutical Sciences, Western University of Health Sciences, Pomona, California, United States of America
⨯

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist

Catherine E. Erickson,
Rukhsana Gul,
Christopher P. Blessing,
Jenny Nguyen,
Tammy Liu,
Lakshmi Pulakat,
Murat Bastepe,
Edwin K. Jackson,
Bradley T. Andresen

Published: August 20, 2013
https://doi.org/10.1371/journal.pone.0071980

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