Enhanced Nasal Mucosal Delivery and Immunogenicity of Anti-Caries DNA Vaccine through Incorporation of Anionic Liposomes in Chitosan/DNA Complexes

Liulin Chen; Junming Zhu; Yuhong Li; Jie Lu; Li Gao; Huibi Xu; Mingwen Fan; Xiangliang Yang

doi:10.1371/journal.pone.0071953

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Open Access

Peer-reviewed

Research Article

Enhanced Nasal Mucosal Delivery and Immunogenicity of Anti-Caries DNA Vaccine through Incorporation of Anionic Liposomes in Chitosan/DNA Complexes

Liulin Chen ,

Contributed equally to this work with: Liulin Chen, Junming Zhu

Affiliation National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, PR China
⨯
Junming Zhu ,

Contributed equally to this work with: Liulin Chen, Junming Zhu

Affiliation National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, PR China
⨯
Yuhong Li,

Affiliation Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, PR China
⨯
Jie Lu,

Affiliation National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, PR China
⨯
Li Gao,

Affiliation National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, PR China
⨯
Huibi Xu,

Affiliation National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, PR China
⨯
Mingwen Fan ,

* E-mail: kqyywjtx@public.wh.hb.cn (MF); yangxl@mail.hust.edu.cn (XY)

Affiliation Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, PR China
⨯
Xiangliang Yang

* E-mail: kqyywjtx@public.wh.hb.cn (MF); yangxl@mail.hust.edu.cn (XY)

Affiliation National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, PR China
⨯

Enhanced Nasal Mucosal Delivery and Immunogenicity of Anti-Caries DNA Vaccine through Incorporation of Anionic Liposomes in Chitosan/DNA Complexes

Liulin Chen,
Junming Zhu,
Yuhong Li,
Jie Lu,
Li Gao,
Huibi Xu,
Mingwen Fan,
Xiangliang Yang

Published: August 20, 2013
https://doi.org/10.1371/journal.pone.0071953

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12 Dec 2013
23:44 GMT
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pH mediated changes? Posted by KP_76 on 12 Dec 2013 at 23:44 GMT

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Transfection
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DNA vaccination
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Nasal mucosa
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Lipids
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Liposomes
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