A Systematically Combined Genotype and Functional Combination Analysis of CYP2E1, CYP2D6, CYP2C9, CYP2C19 in Different Geographic Areas of Mainland China – A Basis for Personalized Therapy

Zhenqiang Wu; Xiaoqing Zhang; Lu Shen; Yuyu Xiong; Xi Wu; Ran Huo; Zhiyun Wei; Lei Cai; Guoyang Qi; Qingqing Xu; Daxiang Cui; Donghong Cui; Gengchun Zhao; Lin He; Shengying Qin

doi:10.1371/journal.pone.0071934

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Peer-reviewed

Research Article

A Systematically Combined Genotype and Functional Combination Analysis of CYP2E1, CYP2D6, CYP2C9, CYP2C19 in Different Geographic Areas of Mainland China – A Basis for Personalized Therapy

Zhenqiang Wu,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Shanghai geno mePilot Institutes for Genomics and Human Health, Shanghai, China
⨯
Xiaoqing Zhang,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Department of Pharmacy, Shanghai pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
⨯
Lu Shen,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Shanghai geno mePilot Institutes for Genomics and Human Health, Shanghai, China
⨯
Yuyu Xiong,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Shanghai geno mePilot Institutes for Genomics and Human Health, Shanghai, China
⨯
Xi Wu,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Shanghai geno mePilot Institutes for Genomics and Human Health, Shanghai, China
⨯
Ran Huo,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Shanghai geno mePilot Institutes for Genomics and Human Health, Shanghai, China
⨯
Zhiyun Wei,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Shanghai geno mePilot Institutes for Genomics and Human Health, Shanghai, China
⨯
Lei Cai,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
⨯
Guoyang Qi,

Affiliation Wuxi Mental Health Center , Wuxi, Jiangsu, PR China
⨯
Qingqing Xu,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Shanghai geno mePilot Institutes for Genomics and Human Health, Shanghai, China
⨯
Daxiang Cui,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, China
⨯
Donghong Cui,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Shanghai Institute of Mental Health, Shanghai, China
⨯
Gengchun Zhao,

Affiliation School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
⨯
Lin He,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Shanghai geno mePilot Institutes for Genomics and Human Health, Shanghai, China, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
⨯
Shengying Qin

* E-mail: chinsir@sjtu.edu.cn

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Shanghai geno mePilot Institutes for Genomics and Human Health, Shanghai, China
⨯

A Systematically Combined Genotype and Functional Combination Analysis of CYP2E1, CYP2D6, CYP2C9, CYP2C19 in Different Geographic Areas of Mainland China – A Basis for Personalized Therapy

Zhenqiang Wu,
Xiaoqing Zhang,
Lu Shen,
Yuyu Xiong,
Xi Wu,
Ran Huo,
Zhiyun Wei,
Lei Cai,
Guoyang Qi,
Qingqing Xu

Published: October 2, 2013
https://doi.org/10.1371/journal.pone.0071934

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