STAT3 Activation Promotes Oncolytic HSV1 Replication in Glioma Cells

Kazuo Okemoto; Benjamin Wagner; Hans Meisen; Amy Haseley; Balveen Kaur; Ennio Antonio Chiocca

doi:10.1371/journal.pone.0071932

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Open Access

Peer-reviewed

Research Article

STAT3 Activation Promotes Oncolytic HSV1 Replication in Glioma Cells

Kazuo Okemoto,

Affiliation Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, James Cancer Hospital/Solove Research Institute/Comprehensive Cancer Center and Wexner Medical Center, the Ohio State University, Columbus, Ohio, United States of America
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Benjamin Wagner,

Affiliation Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, James Cancer Hospital/Solove Research Institute/Comprehensive Cancer Center and Wexner Medical Center, the Ohio State University, Columbus, Ohio, United States of America
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Hans Meisen,

Affiliation Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, James Cancer Hospital/Solove Research Institute/Comprehensive Cancer Center and Wexner Medical Center, the Ohio State University, Columbus, Ohio, United States of America
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Amy Haseley,

Affiliation Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, James Cancer Hospital/Solove Research Institute/Comprehensive Cancer Center and Wexner Medical Center, the Ohio State University, Columbus, Ohio, United States of America
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Balveen Kaur,

Affiliation Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, James Cancer Hospital/Solove Research Institute/Comprehensive Cancer Center and Wexner Medical Center, the Ohio State University, Columbus, Ohio, United States of America
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Ennio Antonio Chiocca

* E-mail: Eachiocca@partners.org

Affiliations Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, James Cancer Hospital/Solove Research Institute/Comprehensive Cancer Center and Wexner Medical Center, the Ohio State University, Columbus, Ohio, United States of America, Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Institute for the Neurosciences at the Brigham, Brigham and Women’s/Faulkner Hospital and Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯

STAT3 Activation Promotes Oncolytic HSV1 Replication in Glioma Cells

Kazuo Okemoto,
Benjamin Wagner,
Hans Meisen,
Amy Haseley,
Balveen Kaur,
Ennio Antonio Chiocca

Published: August 2, 2013
https://doi.org/10.1371/journal.pone.0071932

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Glioma cells
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Viral replication
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Interferons
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STAT signaling
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Transfection
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Glioma
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Viral gene expression
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Phosphorylation
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