Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis

William H. Hoffman; Gregory G. Passmore; David W. Hannon; Monica V. Talor; Pam Fox; Catherine Brailer; Dynita Haislip; Cynthia Keel; Glenn Harris; Noel R. Rose; Irma Fiordalisi; Daniela Čiháková

doi:10.1371/journal.pone.0071905

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Open Access

Peer-reviewed

Research Article

Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis

William H. Hoffman ,

* E-mail: Whoffman@GRU.edu

Affiliation Section of Pediatric Endocrinology, Georgia Regents University (formerly Georgia Health Sciences University), Augusta, Georgia, United States of America
⨯
Gregory G. Passmore,

Affiliation Medical Laboratory, Imaging, and Radiologic Sciences, Georgia Regents University, Augusta, Georgia, United States of America
⨯
David W. Hannon,

Affiliation Section of Pediatric Cardiology, The Brody School Of Medicine, East Carolina University, Greenville, North Carolina, United States of America
⨯
Monica V. Talor,

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Pam Fox,

Affiliation Section of Pediatric Critical Care, The Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
⨯
Catherine Brailer,

Affiliation Section of Pediatric Critical Care, The Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
⨯
Dynita Haislip,

Affiliation Section of Pediatric Critical Care, The Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
⨯
Cynthia Keel,

Affiliation Section of Pediatric Critical Care, The Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
⨯
Glenn Harris,

Affiliation Section of Pediatric Endocrinology, The Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
⨯
Noel R. Rose,

Affiliations Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, The W. Harry Feinstone Department of Molecular Microbiology & Immunology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Irma Fiordalisi,

Affiliation Section of Pediatric Critical Care, The Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
⨯
Daniela Čiháková

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis

William H. Hoffman,
Gregory G. Passmore,
David W. Hannon,
Monica V. Talor,
Pam Fox,
Catherine Brailer,
Dynita Haislip,
Cynthia Keel,
Glenn Harris,
Noel R. Rose

Published: August 27, 2013
https://doi.org/10.1371/journal.pone.0071905

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Cytokines
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Inflammation
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Cytokine therapy
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Diabetes mellitus
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Systemic inflammatory response syndrome
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Tachycardia
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Hypertension
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