Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance In Vitro and Can Be Detected In Vivo

Erin H. Graf; Matthew J. Pace; Bennett A. Peterson; Lindsay J. Lynch; Steve B. Chukwulebe; Angela M. Mexas; Farida Shaheen; Jeffrey N. Martin; Steven G. Deeks; Mark Connors; Stephen A. Migueles; Una O’Doherty

doi:10.1371/journal.pone.0071879

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Open Access

Peer-reviewed

Research Article

Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance In Vitro and Can Be Detected In Vivo

Erin H. Graf,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Matthew J. Pace,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Bennett A. Peterson,

Affiliation Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Lindsay J. Lynch,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Steve B. Chukwulebe,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Angela M. Mexas,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Farida Shaheen,

Affiliation Center for Aids Research, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jeffrey N. Martin,

Affiliation Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America
⨯
Steven G. Deeks,

Affiliation Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America
⨯
Mark Connors,

Affiliation Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Stephen A. Migueles,

Affiliation Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Una O’Doherty

* E-mail: unao@mail.med.upenn.edu

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance In Vitro and Can Be Detected In Vivo

Erin H. Graf,
Matthew J. Pace,
Bennett A. Peterson,
Lindsay J. Lynch,
Steve B. Chukwulebe,
Angela M. Mexas,
Farida Shaheen,
Jeffrey N. Martin,
Steven G. Deeks,
Mark Connors

Published: August 7, 2013
https://doi.org/10.1371/journal.pone.0071879

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