Phosphorylation Status of 72 kDa MMP-2 Determines Its Structure and Activity in Response to Peroxynitrite

Anna Laura Jacob-Ferreira; Marcia Yuri Kondo; Pravas Kumar Baral; Michael N. G. James; Andrew Holt; Xiaohu Fan; Richard Schulz

doi:10.1371/journal.pone.0071794

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Open Access

Peer-reviewed

Research Article

Phosphorylation Status of 72 kDa MMP-2 Determines Its Structure and Activity in Response to Peroxynitrite

Anna Laura Jacob-Ferreira,

Affiliations Department of Pediatrics, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada, Department of Pharmacology, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
⨯
Marcia Yuri Kondo,

Affiliations Department of Pediatrics, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada, Department of Pharmacology, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
⨯
Pravas Kumar Baral,

Affiliation Department of Biochemistry, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
⨯
Michael N. G. James,

Affiliation Department of Biochemistry, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
⨯
Andrew Holt,

Affiliation Department of Pediatrics, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
⨯
Xiaohu Fan,

Affiliations Department of Pediatrics, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada, Department of Pharmacology, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
⨯
Richard Schulz

* E-mail: richard.schulz@ualberta.ca

Affiliations Department of Pediatrics, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada, Department of Pharmacology, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
⨯

Phosphorylation Status of 72 kDa MMP-2 Determines Its Structure and Activity in Response to Peroxynitrite

Anna Laura Jacob-Ferreira,
Marcia Yuri Kondo,
Pravas Kumar Baral,
Michael N. G. James,
Andrew Holt,
Xiaohu Fan,
Richard Schulz

Published: August 27, 2013
https://doi.org/10.1371/journal.pone.0071794

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Phosphorylation
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Phosphatases
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Cysteine
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Proteolysis
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Coomassie Blue staining
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Immunoprecipitation
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Troponin
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Gelatin
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