TNF-α Acts as an Immunoregulator in the Mouse Brain by Reducing the Incidence of Severe Disease Following Japanese Encephalitis Virus Infection

Daisuke Hayasaka; Kenji Shirai; Kotaro Aoki; Noriyo Nagata; Dash Sima Simantini; Kazutaka Kitaura; Yuki Takamatsu; Ernest Gould; Ryuji Suzuki; Kouichi Morita

doi:10.1371/journal.pone.0071643

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Open Access

Peer-reviewed

Research Article

TNF-α Acts as an Immunoregulator in the Mouse Brain by Reducing the Incidence of Severe Disease Following Japanese Encephalitis Virus Infection

Daisuke Hayasaka ,

* E-mail: hayasaka@nagasaki-u.ac.jp

Affiliation Department of Virology, Institute of Tropical Medicine, GCOE program, Leading Graduate School Program, Nagasaki University, Nagasaki, Nagasaki, Japan
⨯
Kenji Shirai,

Affiliation Clinical Research Center, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan.
⨯
Kotaro Aoki,

Affiliation Department of Virology, Institute of Tropical Medicine, GCOE program, Leading Graduate School Program, Nagasaki University, Nagasaki, Nagasaki, Japan
⨯
Noriyo Nagata,

Affiliation Department of Pathology, National Institute of Infectious Diseases Musashimurayama, Tokyo, Japan.
⨯
Dash Sima Simantini,

Affiliation Department of Virology, Institute of Tropical Medicine, GCOE program, Leading Graduate School Program, Nagasaki University, Nagasaki, Nagasaki, Japan
⨯
Kazutaka Kitaura,

Affiliation Clinical Research Center, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan.
⨯
Yuki Takamatsu,

Affiliation Department of Virology, Institute of Tropical Medicine, GCOE program, Leading Graduate School Program, Nagasaki University, Nagasaki, Nagasaki, Japan
⨯
Ernest Gould,

Affiliation UMR 190 Emergence des Pathologies Virales, Aix-Marseille Univ & Institut de Recherche pour le Développement, Marseille, France and NERC CEH, Wallingford, United Kingdom
⨯
Ryuji Suzuki,

Affiliation Clinical Research Center, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan.
⨯
Kouichi Morita

Affiliation Department of Virology, Institute of Tropical Medicine, GCOE program, Leading Graduate School Program, Nagasaki University, Nagasaki, Nagasaki, Japan
⨯

TNF-α Acts as an Immunoregulator in the Mouse Brain by Reducing the Incidence of Severe Disease Following Japanese Encephalitis Virus Infection

Daisuke Hayasaka,
Kenji Shirai,
Kotaro Aoki,
Noriyo Nagata,
Dash Sima Simantini,
Kazutaka Kitaura,
Yuki Takamatsu,
Ernest Gould,
Ryuji Suzuki,
Kouichi Morita

Published: August 5, 2013
https://doi.org/10.1371/journal.pone.0071643

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