cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia

Yijin Tao; Miaozhen Pan; Shufeng Liu; Fang Fang; Runxia Lu; Chanyi Lu; Min Zheng; Jianhong An; Hongjia Xu; Fuxin Zhao; Jiang-fan Chen; Jia Qu; Xiangtian Zhou

doi:10.1371/journal.pone.0071441

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Research Article

cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia

Yijin Tao ,

Contributed equally to this work with: Yijin Tao, Miaozhen Pan

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Miaozhen Pan ,

Contributed equally to this work with: Yijin Tao, Miaozhen Pan

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Shufeng Liu,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Fang Fang,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Runxia Lu,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Chanyi Lu,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Min Zheng,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Jianhong An,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Hongjia Xu,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Fuxin Zhao,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Jiang-fan Chen,

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, Department of Neurology, Boston University, School of Medicine, Boston, Massachusetts, United States of America
⨯
Jia Qu ,

* E-mail: jqu@wz.zj.cn (JQ); zxt-dr@wz.zj.cn (XZ)

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯
Xiangtian Zhou

* E-mail: jqu@wz.zj.cn (JQ); zxt-dr@wz.zj.cn (XZ)

Affiliations School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China, State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China
⨯

cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia

Yijin Tao,
Miaozhen Pan,
Shufeng Liu,
Fang Fang,
Runxia Lu,
Chanyi Lu,
Min Zheng,
Jianhong An,
Hongjia Xu,
Fuxin Zhao

Published: August 12, 2013
https://doi.org/10.1371/journal.pone.0071441

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