17β-Estradiol Enhances Signalling Mediated by VEGF-A-Delta-Like Ligand 4-Notch1 Axis in Human Endothelial Cells

Cristiana Caliceti; Giorgio Aquila; Micaela Pannella; Marco Bruno Morelli; Cinzia Fortini; Paolo Pinton; Massimo Bonora; Silvana Hrelia; Antonio Pannuti; Lucio Miele; Paola Rizzo; Roberto Ferrari

doi:10.1371/journal.pone.0071440

Loading metrics

Open Access

Peer-reviewed

Research Article

17β-Estradiol Enhances Signalling Mediated by VEGF-A-Delta-Like Ligand 4-Notch1 Axis in Human Endothelial Cells

Cristiana Caliceti,

Affiliation Department of Medical Sciences, Cardiovascular Section, Azienda Ospedaliero-Universitaria, Arcispedale Sant’Anna, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
⨯
Giorgio Aquila,

Affiliation Department of Medical Sciences, Cardiovascular Section, Azienda Ospedaliero-Universitaria, Arcispedale Sant’Anna, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
⨯
Micaela Pannella,

Affiliation Department of Medical Sciences, Cardiovascular Section, Azienda Ospedaliero-Universitaria, Arcispedale Sant’Anna, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
⨯
Marco Bruno Morelli,

Affiliation Department of Medical Sciences, Cardiovascular Section, Azienda Ospedaliero-Universitaria, Arcispedale Sant’Anna, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
⨯
Cinzia Fortini,

Affiliation Department of Medical Sciences, Cardiovascular Section, Azienda Ospedaliero-Universitaria, Arcispedale Sant’Anna, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
⨯
Paolo Pinton,

Affiliation Department of Surgeon, Morphology and Experimental Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI), Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
⨯
Massimo Bonora,

Affiliation Department of Surgeon, Morphology and Experimental Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI), Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
⨯
Silvana Hrelia,

Affiliation Department for Life Quality Studies, Alma Mater Studiorum - University of Bologna, Bologna, Italy
⨯
Antonio Pannuti,

Affiliation University of Mississippi, Medical Center Cancer Institute, Jackson, Mississippi, United States of America
⨯
Lucio Miele,

Affiliation University of Mississippi, Medical Center Cancer Institute, Jackson, Mississippi, United States of America
⨯
Paola Rizzo ,

* E-mail: prizzo@mtagroup.net

Affiliation Department of Medical Sciences, Cardiovascular Section, Azienda Ospedaliero-Universitaria, Arcispedale Sant’Anna, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
⨯
Roberto Ferrari

Affiliation Department of Medical Sciences, Cardiovascular Section, Azienda Ospedaliero-Universitaria, Arcispedale Sant’Anna, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
⨯

17β-Estradiol Enhances Signalling Mediated by VEGF-A-Delta-Like Ligand 4-Notch1 Axis in Human Endothelial Cells

Cristiana Caliceti,
Giorgio Aquila,
Micaela Pannella,
Marco Bruno Morelli,
Cinzia Fortini,
Paolo Pinton,
Massimo Bonora,
Silvana Hrelia,
Antonio Pannuti,
Lucio Miele

Published: August 13, 2013
https://doi.org/10.1371/journal.pone.0071440

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Notch signaling
Is the Subject Area "Notch signaling" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Estrogens
Is the Subject Area "Estrogens" applicable to this article?

Thanks for your feedback.
Endothelial cells
Is the Subject Area "Endothelial cells" applicable to this article?

Thanks for your feedback.
Angiogenesis
Is the Subject Area "Angiogenesis" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
RNA extraction
Is the Subject Area "RNA extraction" applicable to this article?

Thanks for your feedback.
Endothelium
Is the Subject Area "Endothelium" applicable to this article?

Thanks for your feedback.