Abrogated Thioredoxin System Causes Increased Sensitivity to TNF-α-Induced Apoptosis via Enrichment of p-ERK 1/2 in the Nucleus

Open Access

Peer-reviewed

Research Article

Min-Hyuk Yoo,

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland, United States of America
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Bradley A. Carlson,

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland, United States of America
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Vadim N. Gladyshev,

Affiliation Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Dolph L. Hatfield

* E-mail: hatfield@mail.nih.gov

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland, United States of America
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Apoptosis
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Breast cancer
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Mitochondria
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ERK signaling cascade
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MAPK signaling cascades
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Redox signaling
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Cancer treatment
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Protein kinase signaling cascade
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