HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP–Positive and –Negative Rheumatoid Arthritis in Chinese Han

Xu Liu; Jianping Guo; Yuan Jia; Yi Zhao; Xia Liu; Feng Cheng; Xiaoxia Li; Yi Zheng; Xuhua Shi; Haiyun Li; Cibo Huang; Yongjing Cheng; Bei Lai; Yanhong Huang; Tian Wang; Bo Ding; ZhangGuo Li

doi:10.1371/journal.pone.0071373

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Open Access

Peer-reviewed

Research Article

HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP–Positive and –Negative Rheumatoid Arthritis in Chinese Han

Xu Liu ,

Contributed equally to this work with: Xu Liu, Jianping Guo

Affiliation Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
⨯
Jianping Guo ,

Contributed equally to this work with: Xu Liu, Jianping Guo

Affiliation Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
⨯
Yuan Jia,

Affiliation Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
⨯
Yi Zhao,

Affiliation Department of Rheumatology, Xuanwu Hospital Capital Medical University, Beijing, China
⨯
Xia Liu,

Affiliation Department of Rheumatology, China-Japan Friendship Hospital, Chaoyang District, Beijing, China
⨯
Feng Cheng,

Affiliation Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Haidian District, Beijing, China
⨯
Xiaoxia Li,

Affiliation Department of Rheumatology, Xuanwu Hospital Capital Medical University, Beijing, China
⨯
Yi Zheng,

Affiliation Department of Rheumatology, Chao-yang Hospital, Chaoyang District, Beijing, China
⨯
Xuhua Shi,

Affiliation Department of Rheumatology, Chao-yang Hospital, Chaoyang District, Beijing, China
⨯
Haiyun Li,

Affiliation Department of Rheumatology, Chao-yang Hospital, Chaoyang District, Beijing, China
⨯
Cibo Huang,

Affiliation Department of Rheumatology, Beijing Hospital of the Ministry of Health, Beijing, China
⨯
Yongjing Cheng,

Affiliation Department of Rheumatology, Beijing Hospital of the Ministry of Health, Beijing, China
⨯
Bei Lai,

Affiliation Department of Rheumatology, Beijing Hospital of the Ministry of Health, Beijing, China
⨯
Yanhong Huang,

Affiliation Department of Rheumatology, Beijing Jishuitan Hospital, Beijing, China
⨯
Tian Wang,

Affiliation Department of Internal Medicine, Beijing Anzhen Hospital Capital Medical University, Beijing, China
⨯
Bo Ding,

Affiliation Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
⨯
[ ... ],
ZhangGuo Li

* E-mail: mailto:liuxu0201@gmail.com

Affiliation Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
⨯
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HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP–Positive and –Negative Rheumatoid Arthritis in Chinese Han

Xu Liu,
Jianping Guo,
Yuan Jia,
Yi Zhao,
Xia Liu,
Feng Cheng,
Xiaoxia Li,
Yi Zheng,
Xuhua Shi,
Haiyun Li

Published: August 12, 2013
https://doi.org/10.1371/journal.pone.0071373

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Haplotypes
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Han Chinese people
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Enzyme-linked immunoassays
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