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Open Access
Peer-reviewed
Research Article
Cognitive Dysfunction Precedes the Onset of Motor Symptoms in the MitoPark Mouse Model of Parkinson’s Disease
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Xiuhua Li,
Affiliations Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, P.R. China
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Laney Redus,
Affiliation Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas, United States of America
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Cang Chen,
Affiliations Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America
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Paul A. Martinez,
Affiliations Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Center for Biomedical Neuroscience, The University of Texas Health Science Center, San Antonio, Texas, United States of America
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Randy Strong,
Affiliations Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Center for Biomedical Neuroscience, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America
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Senlin Li ,
* E-mail: lis1@uthscsa.edu (SL); oconnorj@uthscsa.edu (JO)
Affiliations Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Center for Biomedical Neuroscience, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America
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Jason C. O’Connor
* E-mail: lis1@uthscsa.edu (SL); oconnorj@uthscsa.edu (JO)
Affiliations Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Center for Biomedical Neuroscience, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Mood Disorders Translational Research Core, The University of Texas Health Science Center, San Antonio, Texas, United States of America
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Cognitive Dysfunction Precedes the Onset of Motor Symptoms in the MitoPark Mouse Model of Parkinson’s Disease
- Xiuhua Li,
- Laney Redus,
- Cang Chen,
- Paul A. Martinez,
- Randy Strong,
- Senlin Li,
- Jason C. O’Connor
- Published: August 15, 2013
- https://doi.org/10.1371/journal.pone.0071341