Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway

Rong Shi; Ze-Yong Chen; Dao-Wei Zhu; Chunmin Li; Yufei Shan; Genjun Xu; Sheng-Xiang Lin

doi:10.1371/journal.pone.0071242

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Peer-reviewed

Research Article

Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway

Rong Shi,

Affiliations Laboratory of Molecular Endocrinology and Oncology, Centre Hospitalier Université de Québec Research Center (CHUQ-CHUL), Department of Molecular Medicine and PROTEO, Laval University, Québec City, Canada, Département de Biochimie, de Microbiologie et de Bio-Informatique, IBIS et PROTEO, Université Laval, Pavillon Charles-Eugène Marchand, Québec City, Canada
⨯
Ze-Yong Chen,

Affiliation The Laboratory of Structural Biology for Visiting Scientists at Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai, China
⨯
Dao-Wei Zhu,

Affiliation Département de Biochimie, de Microbiologie et de Bio-Informatique, IBIS et PROTEO, Université Laval, Pavillon Charles-Eugène Marchand, Québec City, Canada
⨯
Chunmin Li,

Affiliation Laboratory of Molecular Endocrinology and Oncology, Centre Hospitalier Université de Québec Research Center (CHUQ-CHUL), Department of Molecular Medicine and PROTEO, Laval University, Québec City, Canada
⨯
Yufei Shan,

Affiliation Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai, China
⨯
Genjun Xu,

Affiliation Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai, China
⨯
Sheng-Xiang Lin

* E-mail: sheng-xiang.lin@crchul.ulaval.ca

Affiliations Laboratory of Molecular Endocrinology and Oncology, Centre Hospitalier Université de Québec Research Center (CHUQ-CHUL), Department of Molecular Medicine and PROTEO, Laval University, Québec City, Canada, The Laboratory of Structural Biology for Visiting Scientists at Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai, China
⨯

Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway

Rong Shi,
Ze-Yong Chen,
Dao-Wei Zhu,
Chunmin Li,
Yufei Shan,
Genjun Xu,
Sheng-Xiang Lin

Published: September 27, 2013
https://doi.org/10.1371/journal.pone.0071242

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